李博涵

发布者:张棕越发布时间:2021-06-07浏览次数:1343

李博涵

一、基本信息

李博涵,博士,中西医结合学院副教授,中西医结合基础专业硕士生导师。中西医结合学院新型抗癌靶点的发现与治疗创新团队成员,主要从事非编码RNA在肿瘤调控中的分子机制研究,以及中药及天然产物抗肿瘤活性成分的筛选及作用机制研究等,在肿瘤药理等方面积累了丰富的经验。主持省级自然科学基金项目1项,校级科研项目1项,参与自然科学基金项目多项。在多个国际权威期刊发表学术论文十余篇,其中以第一/共一或通讯作者发表SCI论文7篇。

二、学术经历

2021-至今 滨州医学院中西医结合学院 副教授

2016-2021年 中国科学院上海药物研究所 药理学博士

2014-2016年 中国科学院上海药物研究所 药理学硕士

三、主持科学研究项目

主持山东省自然科学基金项目(ZR2021QH3231项,校级科研项目(BY2021KYQD131项,参与国家等自然科学基金项目多项。

四、代表性成果

1. Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma. Journal of natural products, 2023. Liu L, Shi D, Xia ZY, Wang BW, Wang XL, Wang XT, Wang GL, Li MJ, Zheng QS, Li D, Li BH.

2. A noncoding regulatory RNA Gm31932 induces cell cycle arrest and differentiation in melanoma via the miR-344d-3-5p/Prc1 (and Nuf2) axis. Cell death & disease, 2022. Wang D#, Chen JF#, Li BH#, Jiang QL, Liu L, Xia ZY, Zheng QS, Li MJ, Li DF.

3. DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation. Diabetes, 2021. Shuai L#, Li BH#, Jiang HW, Yang L, Li J, Li JY.

4. Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue. Acta pharmacologica Sinica, 2020. Li BH, Zhang M, Duan YN, Shuai L, Jiang HW, Li J, et al.

5. James. Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications. Chemical Science, 2020. Weber M#, Han HH#, Li BH#, Odyniec ML, Jarman CF, Yi Zang, et al.

6. SIRT5 regulates brown adipocyte differentiation and browning of subcutaneous white adipose tissue. Diabetes, 2019. Shuai L#, Zhang LN#, Li BH#, Tang CL, Wu LY, Li J, et al.

7. AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue. Frontiers in Physiology, 2018. Wu LY#, Zhang LN#, Li BH#, Jiang HW, Duan YN, Xie ZF, et al.

8. Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity. Journal of Natural Products, 2017. Niu B, Ke CQ, Li BH, Li Y, Yi Y, Luo Y, et al.

9. Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenesis in subcutaneous adipose tissue. Redox biology, 2020. Aquilano K, Sciarretta F, Turchi R, Li BH, Rosina M, Ceci V, et al.

10. Protein Encapsulation: A New Approach for Improving the Capability of Small-Molecule Fluorogenic Probes. Chemical Science, 2020. Han HH, Sedgwick A, Shan Y, Li N, Liu TT, Li BH, et al.