郑秋生

发布者：张棕越发布时间：2021-06-07浏览次数：202

郑秋生


山东寿光人，博士，二级教授，博士生导师，教育部新世纪优秀人才。滨州医学院中西医结合学院院长，新疆特种植物药资源教育部重点实验室主任，兰州大学兼职教授、中国海洋大学教兼职教授，石河子大学特聘教授。医药领域国家科技重大专项“十二五”计划技术管理专家，国家科技奖励评审专家，国家自然科学基金评审专家，国家“863”计划专家库成员，国家学位和研究生教育专家组成员，西北天然药物(中藏药)产业技术创新战略联盟专家技术委员会委员。山东省、河北省、上海市、四川省、重庆市等科技奖励和科技计划评审专家；世界中医药学会网络药理学专业委员会副会长，山东省中医药学会内经专业委员会副会长，山东省心功能研究会健康与养生专业委员会副主任委员等10多个学术团体。主持国家“十一五”支撑计划2项，“973”前期研究计划1项，科技部重大新药创制专项1项，科技型中小企业创业投资引导基金1项，国家自然科学基金5项，省部级研究项目30余项。在国内外学术期刊发表论文300余篇，其中SCI收录论文120余篇；出版专著5部，其中参编国外著作2部；获得省部级科技进步一等奖2项，二等奖5项。指导硕士、博士研究生已毕业100余人。


近年来主持的主要课题情况：

  1. 黑色素瘤分化基因的寻找及分化机制的研究，山东省重点研发计划（2019GSF108214），2019.1-2021.3，第一位。

  2. 新狼毒素A通过NAD+补救信号通路调节能量代谢逆转黑色素瘤恶性表型的机制研究，国家自然科学基金（31870338），2019.01-2022.12，第一位。

  3. 异甘草素调控糖代谢诱导黑色素瘤细胞凋亡机制研究，国家自然科学基金（31471338），2015.01-2018.12，第一位。

  4. 甘草查尔酮A诱导膀胱癌T24细胞凋亡机制研究，国家自然科学基金（81260338）55万元，2012-2016；第一位。

  5. 特种植物药资源重点实验室药物筛选平台建设项目（2012Z027），国家发改委，350万， 2012-2014，第一位。

  6. 光果甘草中三种化合物联合分离新技术研发及中试（13C26216516410），科技型中小企业创业投资引导基金，2014.1-2016.12，第一位。

  7. 异甘草素诱导HL-60细胞分化机制的研究，国际科技合作计划（2012BC001），2012-2014；第一位。

  8. 异甘草素诱导肿瘤细胞从分化到凋亡过程中氧化还原调控机制研究，973计划前期研究专项（2010CB535003），2009-2012，第一位。

  9.  NADPH氧化酶在异甘草素诱导HL-60细胞分化中的作用研究，国家自然科学基金（30960451），2010-2012，第一位。

  10. 化药一类抗肿瘤新药维泰醇及维泰醇类化合物成药性研究，科技部重大新药创制科技重大专项（2009ZX09103-141），2009-2012，第一位。

  11. 活性氧在阿片代谢过程中产生机制及其对阿片受体结合能力的影响 国家自然科学基金（30860074），2009-2011，第一位。

  12. 抗肝纤维化复方新药甘草紫参片的研究与开发 国家“十一五”支撑计划(2006BAI06A18-22)，2007-2009，第一位。


科研奖励：

  1. 基于氧化还原理论的中药活性成分抗肿瘤作用研究，2019年山东省高等学校科学技术奖（证书编号2019BK20059），第1位。

  2. 第五届山东省优秀研究生指导教师，2019年，山东省教育厅。

  3. 基于“医药相长”的中医学专业《中药学》“贯通式”实践教学模式研究，2018年山东省省级教学成果二等奖。

  4.  2016年度兵团科学技术合作奖；新兵发〔2016〕58号,新疆生产建设兵团。      

  5. 精确放疗同步中药优化治疗高危肿瘤与临床防护技术的应用，中国人民解放军医疗成果奖二等奖。2015年，中国人民解放军总后勤部。

  6. 系统药理学理论和氧还调控技术在筛选评价抗肿瘤药物上的应用。2014年兵团科技进步一等奖，第1位。

  7. 中医证候物质基础与中药功效分子网络靶点生物系统学解析, 2014年山东省自然科学二等奖，第1位。

  8. 狼毒灌注RF加温IMCRT治疗肿瘤与战时辐射损伤的相关研究. 2010年全军科技进步二等奖；2010.11.2。

  9. 中药联合SFR并透热加温治疗肿瘤的临床防护研究，2005中华中医药学会科学技术一等奖， 第2位。

  10. 中药灌注RF加温IMCRT治疗肿瘤的防护研究，2009年山东省科学技术进步二等奖（证书编号JB2009-2-113）。

  11.  3D立体放射X(γ)线治疗肿瘤辐射损伤的临床防护研究，2004全军医疗成果科技进步二等奖。

  12. 对口支援西部高校工作十周年突出贡献个人，中华人民共和国教育部，2011年


申报专利情况：

  1. 蟾毒它灵作为抗恶性黑色素瘤药物的应用及其制剂[P]. 山东：CN108743594A,2018-11-06.

  2. 羟基红花黄色素B在制备治疗乳腺癌药物中的应用[P]. 山东：CN108743602A,2018-11-06.

  3. 羟基红花黄色素B在防治心肌缺血再灌注损伤方面的应用[P]. 山东：CN108392486A,2018-08-14.

  4. 一种淫羊藿苷在制备治疗黑色素瘤药物中的应用及药物[P]. 山东：CN107913282A,2018-04-17.

  5. 一种升高葡萄白藜芦醇含量的方法[Z]. CN102047827A: ,2011.

  6. 一种诱导葡萄氐类物质积累的方法，ZL201210380456.6.

  7. 维康醇在抑制肿瘤细胞增殖及周期调控的应用，申请日期2012.4.27

  8. 维泰醇在制备抗肿瘤转移药物中的应用，申请日期2012.4.27

  9. 甘草苷在制备防治脑血栓疾病药物中的应用，CN102716140A，2012.10.10

  10. 甘草苷在制备防治脑缺血疾病药物中的应用，CN102716139A ，2012.10.10  

  11. 壳寡糖在制备防治心脑血管疾病药物中的应用[Z]. CN102210699A: ,2011.

  12. 叶黄素在制备防治脑血管疾病药物中的应用[Z]. CN102210662A: ,2011.

  13. 香青兰总黄酮在制备防治脑血管疾病药物中的应用[Z]. CN102138967A: ,2011.

  14. 甘草苷在制备防治心脑血管疾病药物中的应用[Z]. CN102125576A: ,2011.

      

专著：

  1. Reactive Oxygen Species and Morphine Addiction. Chapter · June 2016. DOI: 10.1201/b20228-45; In book: Reactive Oxygen Species in Biology and Human Health,  Crc Press. Shamim I. AhmadJune 1, 2016 by CRC Press. 

  2.  Neuroprotective Effect of Lavender Oil on Transient Focal Cerebral Ischemia in Mice. In Cerebral Ischemia, Book editor, Maurizio Balestrino, 2012

  3. 自由基毒理学，柯跃斌主编，人民卫生出版社出版，2012

  4. 计算机在生命科学中的应用，山东科技出版社 2001.10

  5. 海洋生物技术进展，化学化工出版社 2005.5

  6. 自由基生物学与医学，高等教育出版社 2007年3月

近5年发表的主要学术论文

2020

  1. Zhaohai Pan, Jiaojiao Fan, Qi Xie, Xin Zhang, Wen Zhang, Qing Ren, Minjing Li,Qiusheng Zheng, Jun Lu, Defang Li. Novel sulfonamide porphyrin TBPoS-2OH used in photodynamic therapy for malignant melanoma. Biomedicine & Pharmacotherapy 133 (2021) 111042,1-10

  2. Xue Hu, Zihui Yang, Wenjing Liu, Zhaohai Pan, Xin Zhang, Minjing Li, Xiaona Liu, Qiusheng Zheng, Defang Li. The Anti-tumor Effects of p-Coumaric Acid on Melanoma A375 and B16 Cells. Front Oncol. 2020 Oct 16;10:558414.

  3. Wenjing Liu, Yang Liu, Zhaohai Pan, Xin Zhang, Yao Qin, Xiaojie Chen, Minjing Li, Xiaoyu Chen, Qiusheng Zheng, Xiaona Liu, Defang Li. Systematic Analysis of tRNA-Derived Small RNAs Discloses New Therapeutic Targets of Caloric Restriction in Myocardial Ischemic Rats. Front Cell Dev Biol. 2020 Nov 3;8:568116.

  4. Yuzhi Wang, Zhaohai Pan, Xiao-Lan Cheng, Kai Zhang, Xin Zhang,Yao Qin, Jiaojiao Fan, Ting Yan, Tao Han, Kwok Keun Shiu, Sam Chun-Kit Haub,Nai-Ki Mak, Daniel W.J. Kwong, Xiaona Liu, Minjing Li, Guowei Deng, Qiusheng Zheng, Jun Lu, Defang Li. A red-light-activated sulfonamide porphycene for highly efficientphotodynamic therapy against hypoxic tumor. European Journal of Medicinal Chemistry. 209 (2021) 112867

  5. LiuXiaon,Che Xiaoqing, Li Kunyu, Wang Xibo, Lin Zhaozhou,Wu Zhisheng, Zheng Qiushewng.Geographical authenticity evaluation of Mentha haplocalyx by LIBS coupled with multivariate analyzes[J].Plasma Science and Technology,2020,22(07):53-59.

  6. Zhaohai Pan, Yongchuan Luo, Yuan Xia, Xin Zhang, Yao Qin, Wenjing Liu, Minjing Li, Xiaona Liu, Qiusheng Zheng, Defang Li．Cinobufagin Induces Cell Cycle Arrest at the S Phase and Promotes Apoptosis in Nasopharyngeal Carcinoma Cells.Biomed Pharmacother. 2020 Feb;122:109763. doi: 10.1016/j.biopha.2019.109763. Epub 2019 Dec 30.

  7. Lingling Si, Xinyan Yan, Yan Wang, Boxue Ren, Huanhuan Ren, Yangfang Ding, Qiusheng Zheng, Defang Li, Ying Liu. Chamaejasmin B Decreases Malignant Characteristics of Mouse Melanoma B16F0 and B16F10 Cells. Front Oncol.; 2020 Apr 2;10:415.  10.3389/fonc.2020.00415. eCollection 2020.

  8. Yangfang Ding, Qi Xie, Wenjing Liu, Zhaohai Pan, Xinmei Fan, Xiaoyu Chen, Mingkai Li, Wei Zhao, Defang Li, Qiusheng Zheng. Neochamaejasmin A Induces Mitochondrial-Mediated Apoptosis in Human Hepatoma Cells via ROS-Dependent Activation of the ERK1/2/JNK Signaling Pathway Oxid Med Cell Longev. 2020 Jan 20;2020:3237150. doi: 10.1155/2020/3237150. eCollection 2020.

2019

  1. Zhaohai Pan, Xin Zhang, Pengfei Yu, Xiaoyu Chen, Peng Lu, Minjing Li, Xiaona Liu, Zhipeng Li, Fei Wei, Kejun Wang, Qiusheng Zheng and Defang Li. Cinobufagin Induces Cell CycleArrest at the G2/M Phase andPromotes Apoptosis in MalignantMelanoma Cells.Frontiers in Oncology. published: 04 September 2019, doi: 10.3389/fonc.2019.00853

  2. Xiaoyu Chen, Ying Chen, Chuanjun Qu, Zhaohai Pan, Yao Qin, Xin Zhang,Wenjing Liu, Defang Li and Qiusheng Zheng. Vitamin C induces human melanoma A375 cell apoptosis via Bax  and Bcl 2 mediated mitochondrial pathways. ONCOLOGY LETTERS 18: 3880  3880-3886, 2019, Received November 8, 2018; Accepted June 13, 2019

  3. Zhang X, Qin Y, Pan Z, Li M, Liu X, Chen X, Qu G, Zhou L, Xu M, Zheng Q, Li D. Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25;9(8). pii: E302. doi: 10.3390/biom9080302.

  4. Qu C, Zhu W, Dong K, Pan Z, Chen Y, Chen X, Liu X, Xu W, Lin H, Zheng Q, Li D. Inhibitory Effect of Hydroxysafflor Yellow B on the Proliferation of Human Breast Cancer MCF-7 Cells. Recent Pat Anticancer Drug Discov. 2019;14(2):187-197. doi: 10.2174/1574891X14666190516102218.

  5. Minjing Li, Jinliang Chen, Xiaofei Yu, Sen Xu, Defang Li, Qiusheng Zheng,*and Yancun Yin,* Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP. Cells 2019, 8(4), 358;

  6. Li Liu, Dan Wang, Yao Qin, Maolei Xu, Ling Zhou, Wenjuan Xu, Xiaona Liu, Lei Ye, Shijun Yue, Qiusheng Zheng and Defang Li. Astragalin Promotes Osteoblastic Differentiation in MC3T3-E1 Cells and Bone Formation in vivo. Front. Endocrinol., 16 April 2019 | https://doi.org/10.3389/fendo.2019.00228

  7. Boxue Ren，Lei Ye，Jianwei Gong，Huanhuan Ren，Yangfang Ding，Xiaoyu Chen，Xiaona Liu，Peng Lu，Fei Wei， Wenjuan Xu，Qiusheng Zheng，Defang Li. Alteronol Enhances the Anti-tumor Activity and Reduces the Toxicity of High-Dose Adriamycin in Breast Cancer. Front Pharmacol. 2019 Mar 29;10:285. doi: 10.3389/fphar.2019.00285.

  8. Chen XY, Ren HH, Wang D, Chen Y, Qu CJ, Pan ZH, Liu XN, Hao WJ, Xu WJ, Wang KJ, Li DF, Zheng QS. Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells. Oxid Med Cell Longev. 2019 Jan 21;2019:9817576. doi: 10.1155/2019/9817576.

  9. Zhaohai Pan Chuanjun Qu Ying Chen Xiaoyu Chen Xiaona Liu Wenjin Hao Wenjuan Xu Lei Ye Peng Lu Defang Li Qiusheng Zheng. Bufotalin induces cell cycle arrest and cell apoptosis in human malignant melanoma A375 cells. Oncology Reports, February 2019, DOI: 10.3892/or.2019.7032

  10. Ding, X ; Sun, XL; Wang, ZE ; Zheng, QS; Yu, XF; Hao, WJ; Wang, K ; Xu, WJ; Dong, ZP. The Effects of Wumei Pill on TLRs/NF-kB Signaling Pathway in Rats with Diarrhea-Predominant Irritable Bowel Syndrome. PAKISTAN JOURNAL OF ZOOLOGY. 2019: 51(1): 57-65, DOI: 10.17582/journal.pjz/2019.51.1.57.65

2018

  1. Kai Li, Qiusheng Zheng, Xiaoyu Chen, Yunchao Wang, Dan Wang, and Jianning Wang. Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells. Oxidative Medicine and Cellular Longevity. Volume 2018, Article ID 1915828, 13 pages, https://doi.org/10.1155/2018/1915828

  2. Wang D, Zhang X, Qu D, Han J, Meng F, Xu M, Zheng Q. Astragalin and dihydromyricetin as adjuncts to histidine tryptophan ketoglutarate cardioplegia enhances protection during cardioplegic arrest. Mol Med Rep. 2018 Sep;18(3):2929-2936. doi: 10.3892/mmr.2018.9254.

  3. Liu X, Wang S, Wu Z, Wang Z, Zheng Q, Li D. Deoxyschizandrin Loaded Liposomes on the Suppression Lipid Accumulation in 3T3-L1 Adipocytes. Molecules. 2018 Aug 27;23(9). pii: E2158.

  4. Ren H, Ma J, Si L, Ren B, Chen X, Wang D, Hao W, Tang X, Li D, Zheng Q. Low dose of acacetin promotes breast cancer MCF-7 cells proliferation through the activation of ERK/ PI3K /AKT signaling pathway. Recent Pat Anticancer Drug Discov. 2018;13(3):368-377. doi: 10.2174/1574892813666180420154012.

  5. Li D, Lu N, Han J, Chen X, Hao W, Xu W, Liu X, Ye L, Zheng Q.Eriodictyol Attenuates Myocardial Ischemia-Reperfusion Injury through the Activation of JAK2.Front Pharmacol. 2018 Jan 30;9:33. doi: 10.3389/fphar.2018.00033.

  6. Ren B, Li D, Si L, Ding Y, Han J, Chen X, Zheng Q. Alteronol induces cell cycle arrest and apoptosis via increased reactive oxygen species production in human breast cancer T47D cells. J Pharm Pharmacol. 2018 Apr;70(4):516-524. doi: 10.1111/jphp.12879. 7.

  7. Si L, Yan X, Hao W, Ma X, Ren H, Ren B, Li D, Dong Z, Zheng Q. Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells. Oncol Rep. 2018 May;39(5):2160-2170. doi: 10.3892/or.2018.6329.

2017

  1. Dan Wang, Chendong Yang, Zhuien Wang, Yi Yang, Defang Li, Xiaojie Ding, Wenjuan Xu, Qiusheng Zheng. Norcantharidin combined with Coix seed oil synergistically induces apoptosis and inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation. Scientific Reports 7, Article number: 9373 (2017), doi:10.1038/s41598-017-09668-2

  2. Dong Wang, Xinjie Zhang, Defang Li, Wenjin Hao, Fanqing Meng, Bo Wang,Jichun Han, and Qiusheng Zheng. Kaempferide Protects against Myocardial Ischemia/ReperfusionInjury through Activation of the PI3K/Akt/GSK-3β Pathway. Mediators Inflamm. 2017;2017:5278218. doi: 10.1155/2017/5278218.

  3. Dan Wang, Wenjuan Xu, Xiaoyu Chen, Jichun Han, Lina Yu, Caixia Gao, WenjinHao, Xiaona Liu, Qiusheng Zheng and Defang Li. Icariin induces cell differentiation and cell cycle arrest in mouse melanoma B16 cells via Erk1/2-p38-JNK-dependent pathway. Oncotarget. 2017 Aug 10;8(59):99504-99513. doi: 10.18632/oncotarget.20118.

  4. Han J, Wang D, Li D, Chen X, Wang B, Wang F, Liu X, Shang J, Zheng Q. Licochalcone E protects against carbon tetrachloride induced liver toxicity by activating peroxisome proliferator-activated receptor gamma. Mol Med Rep. 2017 Oct;16(4):5269-5276. doi: 10.3892/mmr.2017.7268.

  5. Han J, Wang D, Ye L, Li P, Hao W, Chen X, Ma J, Wang B, Shang J, Li D, Zheng Q.Rosmarinic Acid Protects against Inflammation and Cardiomyocyte Apoptosis during Myocardial Ischemia/Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma.Front Pharmacol. 2017 Jul 11;8:456. doi: 10.3389/fphar.2017.00456. Lingling Si, Xinhui Yang, Xinyan Yan, Yanming Wang, Qiusheng Zheng. Isoliquiritigenin induces apoptosis of human bladder cancer T24 cells via the Cyclin-dependent kinases-independent mechanism. Oncology Letters. Published online on: May 12, 2017     https://doi.org/10.3892/ol.2017.6159

  6. Wang J, Li Y, Yang Y, Chen X, Du J, Zheng Q, Liang Z, Wang Y.A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula.Sci Rep. 2017 May 4;7(1):1504. doi: 10.1038/s41598-017-01613-7.

  7. Chen XY, Li DF, Han JC, Wang B, Dong ZP, Yu LN, Pan ZH, Qu CJ, Chen Y, Sun SG, Zheng QS.Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling.Oncotarget. 2017 May 23;8(21):34565-34575. doi: 10.18632/oncotarget.16655.

2016

  1. Caixia Gao, Xinyan Yan, Bo Wang, Lina Yu, Jichun Han, Defang Li, Qiusheng Zheng: Jolkinolide B induces apoptosis and inhibits tumor growth in mouse melanoma B16F10 cells by altering glycolysis. Scientific Reports 11/2016; 2016(6:36114 | DOI: 10.1038/srep36114)., DOI:10.1038/srep36114

  2. Lina Yu, Jun Ma, Jichun Han, Bo Wang, Xiaoyu Chen, Caixia Gao, Defang Li, Qiusheng Zheng: Licochalcone B Arrests Cell Cycle Progression and Induces Apoptosis in Human Breast Cancer MCF-7 Cells. Recent Pat Anticancer Drug Discov. 09/2016; 11(4)., DOI:10.2174/1574892811666160906091405

  3. Shi-Liang Jia, Xue-Ling Wu, Xiao-Xiao Li, Xue-Ling Dai, Zhao-Lan Gao, Zheng Lu, Qiu-Sheng Zheng, Ya-Xuan Sun: Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-β1-42 oligomers injected into the hippocampus. Journal of Asian natural products research 09/2016; 18(12)., DOI:10.1080/10286020.2016.1201811

  4. Jichun Han, Defang Li, Xiaoyu Chen, Fanqing Meng, Bo Wang, Xinjie Zhang, Qiusheng Zheng: Effects of Licochalcone A on Cell-cycle Distribution and Glycolysis in Human Bladder Cancer T24 Cells. Journal of food and nutrition research 08/2016; 4(8)., DOI:10.12691/jfnr-4-8-9

  5. Jichun Han, Defang Li, Xiaoyu Chen, Fanqing Meng, Bo Wang, Xinjie Zhang, Qiusheng Zheng: Hepatoprotective Activities of Huoshan Dendrobium Officinale Kimura et Migo Water Extracts on Carbontetrachloride-induced Hepatotoxicity in Mice.. DOI:10.12691/jfnr-4-8-10

  6. Xiaoyu Chen, Ming Yang, Wenjin Hao, Jichun Han, Jun Ma, Caixia Wang, Shiguo Sun, Qiusheng Zheng: Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq. Gene 07/2016; 592(1)., DOI:10.1016/j.gene.2016.07.052

  7. Caixia Wang, Wenjuan Xu, Wenjin Hao, Bingsheng Wang, Qiusheng Zheng: Alternol inhibits the proliferation and induces the differentiation of the mouse melanoma B16F0 cell line. Oncology Reports 06/2016; 36(2)., DOI:10.3892/or.2016.4844

  8. Xinhui Yang, Jiangtao Jiang, Xinyan Yang, Jichun Han, Qiusheng Zheng: Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels. Molecular Medicine Reports 05/2016; 14(1)., DOI:10.3892/mmr.2016.5334

  9. Yanming WANG, Jun MA, Xinyan YAN, Xiaoyu CHEN, Lingling SI, Ying LIU, Jichun HAN, Wenjin HAO, Qiusheng ZHENG: Isoliquiritigenin inhibits proliferation and induces apoptosis via alleviating hypoxia and reducing glycolysis in melanoma B16F10 cells. Recent Patents on Anti-Cancer Drug Discovery 03/2016; 11(999)., DOI:10.2174/1573406412666160307151904

  10. Wenjuan Wang, Xiaotang Ma, Jichun Han, Mingjie Zhou, Huanhuan Ren, Qunwen Pan, Chunli Zheng, Qiusheng Zheng: Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor. PLoS ONE 01/2016; 11(1)., DOI:10.1371/journal.pone.0146197

2015

  1. Shiliang Jia, Zheng Lu, Zhaolan Gao, Jun An, Xueling Wu, Xiaoxiao Li, Xueling Dai, Qiusheng Zheng, Yaxuan Sun. Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-β1-42-induced rat model of Alzheimer's disease. Int J Biol Macromol. 2016 Feb;83:416-25. doi: 10.1016/j.ijbiomac.2015.11.011. Epub 2015 Nov 18.

  2. Yun Han, Jun Wu, Tingting Liu, Youdong Hu, Qiusheng Zheng, Binsheng Wang, Haiyan Lin, Xia Li. Separation, characterization and anticancer activities of a sulfated polysaccharide from Undaria pinnatifida.  Int J Biol Macromol. 2016 Feb;83:42-9. doi: 10.1016/j.ijbiomac.2015.11.049. Epub 2015 Nov 23.

  3. Daoxu Qu, Jichun Han, Huanhuan Ren, Wenxiao Yang, Xinjie hang, Qiusheng Zheng, Dong Wang. Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart. Oxid Med Cell Longev. 2016;2016:8194690. doi: 10.1155/2016/8194690.

  4. Penglong Wang, Xuan Yuan, Yan Wang, Hong Zhao, Xiling Sun, Qiusheng Zheng: Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells. Molecular Medicine Reports 09/2015; 12(5). DOI:10.3892/mmr.2015.4346

  5. Xuan Yuan, Hai-tao Niu, Peng-long Wang, Jie Lu, Hong Zhao, Shi-han Liu, Qiu-sheng Zheng, Chang-gui Li: Cardioprotective Effect of Licochalcone D against Myocardial Ischemia/Reperfusion Injury in Langendorff-Perfused Rat Hearts. PLoS ONE 06/2015; 10(6):e0128375. DOI:10.1371/journal.pone.0128375

  6. Wenjin Hao, Xuan Yuan, Lina Yu, Caixia Gao, Xiling Sun, Dong Wang, Qiusheng Zheng: Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. Scientific Reports 05/2015; 5:10336. DOI:10.1038/srep10336

  7. Mingjie Zhou, Liqun Liu, Wenjuan Wang, Jichun Han, Huanhuan Ren, Qiusheng Zheng, Dong Wang: Role of licochalcone C in cardioprotection against ischemia / reperfusion injury of isolated rat heart via antioxidant, anti-inflammatory, and anti-apoptotic activities. Life sciences 04/2015; 132. DOI:10.1016/j.lfs.2015.04.008

  8. Mingjie Zhou, Huanhuan Ren, Jichun Han, Wenjuan Wang, Qiusheng Zheng, Dong Wang: Protective Effects of Kaempferol against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3. Oxidative medicine and cellular longevity 03/2015; Article ID 481405(1):1-8. DOI:10.1155/2015/481405

  9. Xuejiao Hou, Jichun Han, Changsheng Yuan, Huanhuan Ren, Ya Zhang, Tao Zhang, Lixia Xu, Qiusheng Zheng, Wen Chen: Cardioprotective Effects of Total Flavonoids Extracted from Xinjiang Sprig Rosa rugosa against Acute Ischemia/Reperfusion-Induced Myocardial Injury in Isolated Rat Heart. Cardiovascular toxicology 01/2015;  DOI:10.1007/s12012-015-9308-0

  10. Ma jun, Yuan Xuan, Qu Hengyi, Zhang juan, Wang dong, Sun Xiling, Zheng Qiusheng: The role of reactive oxygen species in morphine addiction of SH-SY5Y cells. Life sciences 01/2015; 124. DOI:10.1016/j.lfs.2015.01.003