李德芳

发布者:张棕越发布时间:2021-06-17浏览次数:19


李德芳,男,博士,教授,泰山学者青年专家,山东省省属优青,山东省高等学校优势学科人才团队学术带头人,烟台市双百计划创新人才,烟台市肿瘤代谢中药药理重点实验室主任。

导师:果德安

毕业院校:中国药科大学
社会兼职:世界中医药联合会骨质疏松专业委员会常务理事、世界中医药联合会网络药理学专业委员会理事、山东药理学会理事、山东药理学会中药药理专业委员会委员

主持课题及成果概况:主持国家自然科学基金面上项目、国家自然科学基金青年基金、山东省自然科学基金省属高校优秀青年人才联合基金项目等项目9项,总经费达1500万元。曾获美国骨矿学年会青年学者奖,省级科技进步奖二等奖1项,省高等学校优秀科研成果奖一等奖1项和二等奖1项,参与申报专利12项,已授权4项。目前共计发表100余篇学术论文,其中SCI收录论文66篇。


1. 论文列表

  1. Systematic Analysis of tRNA-Derived Small RNAs Discloses New Therapeutic Targets of Caloric Restriction in Myocardial Ischemic Rats. Frontiers in Cell and Developmental Biology. 2020 Nov 3. Wenjing Liu, Yang Liu, Zhaohai Pan, Xin Zhang, Yao Qin, Xiaojie Chen, Minjing Li, Xiaoyu Chen, Qiusheng Zheng, Xiaona Liu, Defang Li (Corresponding author).

  2. A red-light-activated sulfonamide porphycene for highly efficient photodynamic therapy against hypoxic tumor. European Journal of Medicinal Chemistry, 2021 Jan 1. Yuzhi Wang, Zhaohai Pan, Xiao-Lan Cheng, Kai Zhang, Xin Zhang, Yao Qin, Jiaojiao Fan, Ting Yan, Tao Han, Kwok Keung Shiu, Sam Chun-Kit Hau, Nai-Ki Mak, Daniel W.J. Kwong, Xiaona Liu, Minjing Li, Guowei Deng, Qiusheng Zheng, Jun Lu, Defang Li (Corresponding author).

  3. Neochamaejasmin A Induces Mitochondrial-Mediated Apoptosis in Human Hepatoma Cells via ROS-Dependent Activation of the ERK1/2/JNK Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2020 Jan 20. Yangfang Ding, Qi Xie, Wen jing Liu, Zhaohai Pan, Xinmei Fan, Xiaoyu Chen, Mingkai Li, Wei Zhao, Defang Li (Corresponding author), Qiusheng Zheng.

  4. The Anti-tumor Effects of p-Coumaric Acid on Melanoma A375 and B16 Cells. Frontiers in Oncology. 2020 Oct 16. Xue Hu, Zihui Yang, Wenjing Liu, Zhaohai Pan, Xin Zhang, Minjing Li, Xiaona Liu, Qiusheng Zheng, Defang Li (Corresponding author).

  5. Cinobufagin Induces Cell Cycle Arrest at the S Phase and Promotes Apoptosis in Nasopharyngeal Carcinoma Cells. Biomedicine & Pharmacotherapy. 2020 Feb. Zhaohai Pan, Yongchuan Luo, Yuan Xia, Xin Zhang, Yao Qin, Wenjing Liu, Minjing Li, Xiaona Liu, Qiusheng Zheng, Defang Li (Corresponding author).

  6. A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-κB signaling pathway. Brain, Behavior, and Immunity. 2019 Feb 7. Zhipeng Li, Shifeng Chu, Wenbin He, Zhao Zhang, Jiaqi Liu, Liyuan Cui, Xu Yan, Defang Li (Corresponding author), Naihong Chen.

  7. Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells. Oxidative Medicine and Cellular Longevity. 2019 Jan 21. Xiao-Yu Chen, Huan-Huan Ren, Dan Wang, Ying Chen, Chuan-Jun Qu, Zhao-Hai Pan, Xiao-Na Liu, Wen-Jin Hao, Wen-Juan Xu, Ke-Jun Wang, Defang Li (Corresponding author), and Qiu-Sheng Zheng.

  8. X Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25. Xin Zhang, Yao Qin, Zhaohai Pan, Minjing Li, Xiaona Liu, Xiaoyu Chen, Guiwu Qu, Ling Zhou, Maolei Xu, Qiusheng Zheng, and Defang Li (Corresponding author).

  9. Alteronol Enhances the Anti-tumor Activity and Reduces the Toxicity of High-Dose Adriamycin in Breast Cancer. Frontiers in Pharmacology. 2019 Mar 29. Boxue Ren, Lei Ye, Jianwei Gong, Huanhuan Ren, Yangfang Ding, Xiaoyu Chen, Xiaona Liu, Peng Lu, Fei Wei, Wenjuan Xu, Qiusheng Zheng and Defang Li (Corresponding author).

  10. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nature Communications. 2016 Mar 7. Defang Li, Jin Liu, Baosheng Guo, Chao Liang, Lei Dang, Cheng Lu, Xiaojuan He, Hilda Yeuk-Siu Cheung, Liang Xu, Changwei Lu, Bing He, Biao Liu, Atik Badshah Shaikh, Fangfei Li, Luyao Wang, Zhijun Yang, Doris Wai-Ting Au, Songlin Peng, Zongkang Zhang, Bao-Ting Zhang, Xiaohua Pan, Airong Qian, Peng Shang, Lianbo Xiao, Baohong Jiang, Chris Kong-Chu Wong, Jiake Xu, Zhaoxiang Bian, Zicai Liang, De-an Guo, Hailong Zhu, Weihong Tan, Aiping Lu, Ge Zhang.

     

    2. 课题、获奖及专利列表

  11. 基于“lncRNA-miRNA-mRNA”调控网络探讨lncRNA-NC_131014在黑色素瘤细胞分化治疗中的作用机制,国家自然科学基金委员会,2021.01—2024.12,李德芳。

  12. LncRNA参与miR-29b-3p调控乳腺癌骨转移的机制研究,国家自然科学基金委员会,2019.01—2022.12,李德芳。

  13. miR-214-3p通过调控破骨细胞分化对乳腺癌溶骨性骨转移的影响,国家自然科学基金委员会,2017.01—2019.12,李德芳。

  14. miRNAs在乳腺癌溶骨性骨转移中的作用及其机制研究,山东省自然科学基金委员会,2017.08—2020.08,李德芳。

  15. 山东省泰山学者青年专家,山东省人民政府,2018.12,李德芳。

  16. 202012月,基于特异性癌基因及其信号转导通路的抗肿瘤靶向治疗,2020年度山东省高等学校科学技术奖,本科高校类,一等奖,获奖者:尹彦存、李敏敬、李德芳、王跃嗣、李春灵、陈金梁,证书编号:2020BK10061

  17. 201912月,基于氧化还原理论的中药活性成分抗肿瘤作用研究,2019年度山东省高等学校科学技术奖,本科高校类,二等奖,获奖者:郑秋生、李德芳、陈小宇、张波、陈红梅、徐文娟、王丹,证书编号:2019BK20059

  18. 一种水溶性卟啉烯衍生物、制备方法、抗肿瘤药物和应用. 专利号:ZL201910806827.4, 授权号:CN110483531B, 授权时间:20200804. 申请(专利权)人: 李德芳, 王雨之, 发明人: 王雨之, 李德芳, 鲁军.

  19. 羟基红花黄色素B在制备治疗胃癌药物中的应用及药物. 专利号: ZL201910071586.3, 授权号: CN109602737B, 授权时间:20210219. 申请(专利权)人: 滨州医学院, 发明人: 李德芳, 郑秋生, 陈小宇, 曲传俊, 刘晓娜, 李志鹏.

  20. 羟基红花黄色素B在制备治疗乳腺癌药物中的应用. 专利号: ZL201810980739.1, 公开号: CN108743602B, 授权时间:20210226.申请(专利权)人: 滨州医学院, 发明人: 李德芳, 郑秋生, 曲传俊, 陈小宇, 刘晓娜, 叶蕾.