李敏敬

发布者:张棕越发布时间:2021-06-06浏览次数:31



李敏敬简历

Ø基本情况

姓名:李敏敬   性别:女  出生年月:1982/09/12    民族:汉    

政治面貌:中共党员    学历:博士研究生  联系电话:15553572836                    

地址:山东省烟台市莱山区观海路346号,264003.    

邮箱:liminjing512@126.com

研究方向:白血病干细胞特异性分子;肿瘤分子信号转导与靶向治疗.

Ø 教育经历

2009/09 - 2012/07,   四川大学,   细胞生物学, 博士, 导师:扬富

2006/09 - 2009/07,   四川大学,   细胞生物学, 硕士, 导师:扬富

2002/09 - 2006/07  河南师范大学,生物科学,学士

Ø 工作经历

2020/01--------今,   滨州医学院,中西医结合学院,副教授

2014/07-2019/12,   滨州医学院,医药研究中心,  讲师

2012/09-2014/06,   苏州大学,  公共卫生学院,  讲师

Ø 科研成果

1,主持科研项目

1.山东省教育厅“青创人才引育计划”,中药抗肿瘤研究创新团队,2019/09—2022/09, 200万,在研,团队带头人。

2. 山东省自然科学基金-面上项目,ZR2020MH120紧密蛋白claudin-4调控AML发展的作用机制研究,10万,2021/01-2023/12在研,项目负责人。

3. 国家自然科学基金青年基金项目,31501146ACER3调节急性髓系白血病干细胞多能性的作用及分子机制,2015-09-01--2018-12-3124,已结题,项目负责人

4.山东省自然科学基金中青年科学家科研奖励基金,BS2015YY013acer3调节急性髓系白血病()细胞的作用及分子机制,2015-07--2017-077万,结题,项目负责人。

 

2, 通讯/第一作者论文

1. Li Minjing, Hao Shiyu, Li Chunling, Xiao Huimin, Sun Liyuan, Yu Zhenhai, Zhang Naili, Xiong Yanlian, Zhao Dongmei*, Yin Yancun*. Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells. Biomolecules. 2019, 19;9(9). pii: E505. (SCI,二区)

2. Li Minjing, Chen Jinliang, Yu Xiaofei, Xu Sen, Li Defang, Zheng Qiusheng*, Yin Yancun*. Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP. Cells. 2019;8(4), pii: E358.(二区, IF=5.656

3. Minjing Li, Ju Gao, Defang Li, Yancun Yin*. CEP55 Promotes Cell Motility via JAK2–STAT3–MMPs Cascade in Hepatocellular Carcinoma. Cells. 2018;7(8), pii: E99. (二区, IF=5.656)

4. Minjing Li, Changzhu Jin, Maolei Xu, Ling Zhou, Defang Li, Yancun Yin*, Bifunctional Enzyme ATIC Promotes Propagation of Hepatocellular Carcinoma by Regulating AMPK-mTOR-S6K1 Signaling. Cell Commun Signal, 2017;15:52-65. (二区, IF=5.324)

5. Yancun Yin, Chen Chen, Jinliang Chen, Renhui Zhan, Qiang Zhang, Xiaoyan Xu, Defang Li, Minjing Li*. Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR. Cell Signal, 2017;35:154-162. (二区 SCI, IF=3.487)

6. Yancun Yin, Ling Zhou, Renhui Zhan, Qiang Zhang, Minjing Li*, Identification of WDR12 as a novel oncogene involved in hepatocellular carcinoma propagation. Cancer Manag Res, 2018;10:39853993. (二区,IF=2.243)

7. Yancun Yin, Maolei Xu, Ju Gao, Minjing Li*. Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling. Pathol Res Pract. 2018;214(9):1381-1387. (SCI; IF=1.794)

8. Hanhan Dai1,*, Minjing Li3,*, Wei Yang1,*, Xiucui Sun1,*, Peiyuan Wang1, Xia Wang4, Jiaqi Su1, Xu Wang1, Xuemei Hu2, Mingdong Zhao1. Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling. AGING 2020, Vol. 12, No. 12. 11717-11731. (二区, IF=5.656

9. Xie Lulu#Dai Hanhan#, Li Minjing#, Yang Wei, Yu Guohua, Wang Xia, Wang Peiyuan, Liu Wei, Hu Xuemei*, Zhao Mingdong*. MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-beta-catenin pathways. J. Cell. Mol. Med. 2019; 23: 3386-3401. (SCIIF=4.658)

10. Lijie Dong†, Lulu Xie†, Minjing Li†, Hanhan Dai, xia wang, Pei-Yuan Wang, Qiang Zhang, Wei Liu, Xuemei Hu, and Mingdong Zhao. Downregulation of B7-H4 suppresses tumor progression of hepatocellular carcinoma. Scientific Reports. 2019 Oct 16;9(1):14854. doi: 10.1038/s41598-019-51253-2.

11. Xie Lulu#Li Minjing#, Liu Desheng, Wang Xia, Wang Peiyuan, Dai Hanhan, Yang Wei, Liu Wei, Hu Xuemei*, Zhao Mingdong*. secalonic acid-f, a novel mycotoxin, represses the progression of hepatocellular carcinoma via march1 regulation of the pi3k/akt /beta-catenin signaling pathway. Molecules, 2019; 24: DOI: 10.3390/molecules24030393. (SCI, IF=3.06)

12. Li Minjing#, Yin Yancun#, Hua Hui, Sun Xiangming, Luo Ting, Wang Jiao, Jiang Yangfu. The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling. J Biol. Chem. 2010; 285:30480-30488. (SCIIF=5.328)

13. Li Minjing, Wang J, Jing J, Hua H, Luo T, Xu L, Wang R, Liu D, Jiang Y. Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70. J. Cell. Mol. Med. 2009; 13: 4540-4550. (SCIIF=5.228)

14. Li Minjing, Yin Yancun, Wang Jiao, Jiang Yangfu. Green tea compounds in breast cancer prevention and treatment. World J Clin Oncol. 2014;5:520-528. Medline

Ø 荣誉奖励

1. 2020年山东省高等学校优秀科研成果奖,基于特异性癌基因及其信号转导通路的抗肿瘤靶向治疗,一等奖,山东省教育厅,尹彦存,李敏敬,李德芳,王跃嗣,李春灵,陈金梁。

2. 2020年,MARCH1在肝细胞癌发生发展中的作用机制研究,山东省优秀硕士毕业论文,山东省教育厅,谢鹭鹭,指导教师:赵明东,李敏敬。

3. 2020年中西医结合学院年度考核优秀。

4. 2016年滨州医学院先进工作者。

5. 2011联合抑制GRP78HSP70促进乳腺癌细胞凋亡的研究, 四川省优秀硕士毕业论文,四川省教育厅, 李敏敬指导教师:蒋扬富。