姓名：陈小宇，性别：女，博士，讲师，西北农林科技大学化学与药学院，主持山东省自然科学基金青年基金（项目编号：ZR2020QH326）一项。
1. 论文列表
Xiao-Yu Chen, Huan-Huan Ren, Dan Wang, Ying Chen, Chuan-Jun Qu, Zhao-Hai Pan, Xiao-Na Liu, Wen-Jin Hao, Wen-Juan Xu, Ke-Jun Wang, De-Fang Li, Qiu-Sheng Zheng. Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells. Oxid Med Cell Longev. 2019 Jan 21;2019:9817576.
1) Xiao-Yu Chen, Ying Chen, Chuan-Jun Qu, Zhao-Hai Pan, Yao Qin, Xin Zhang, Wen-Jing Liu, De-Fang Li, Qiusheng Zheng. Vitamin C induces human melanoma A375 cell apoptosis via Bax- and Bcl-2-mediated mitochondrial pathways. Oncol Lett. 2019 Oct;18(4):3880-3886.
2) Xiaoyu Chen, Ming Yang, Wenjin Hao, Jichun Han, Jun Ma, Caixia Wang, Shiguo Sun, Qiusheng Zheng. Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq. Gene. 2016 Oct 30;592(1):86-98.
3) Xiaoyu Chen, Bo Zhang, Xuan Yuan, Fan Yang, Jinglei Liu, Hong Zhao, Liangliang Liu, Yanming Wang, Zhenhua Wang, Qiusheng Zheng. Isoliquiritigenin-induced differentiation in mouse melanoma B16F0 cell line. Oxid Med Cell Longev. 2012;2012:534934.
4) 陈小宇，陈颖，曲传俊，李德芳，郑秋生. 臭椿酮诱导人黑色素瘤A375细胞凋亡及其机制研究. 天然产物研究与开发. 2019,31(08).
5) Yangfang Ding, Qi Xie, Wenjing Liu, Zhaohai Pan, Xinmei Fan, Xiaoyu Chen, Mingkai Li, Wei Zhao, Defang Li, Qiusheng Zheng. Neochamaejasmin A Induces Mitochondrial-Mediated Apoptosis in Human Hepatoma Cells via ROS-Dependent Activation of the ERK1/2/JNK Signaling Pathway. Oxid Med Cell Longev. 2020 Jan 20;2020:3237150.
6) Zhaohai Pan, Xin Zhang, Pengfei Yu, Xiaoyu Chen, Peng Lu, Minjing Li, Xiaona Liu, Zhipeng Li, Fei Wei, Kejun Wang, Qiusheng Zheng, Defang Li. Cinobufagin Induces Cell Cycle Arrest at the G2/M Phase and Promotes Apoptosis in Malignant Melanoma Cells. Front Oncol. 2019 Sep 4;9:853.
7) Xin Zhang, Yao Qin, Zhaohai Pan, Minjing Li, Xiaona Liu, Xiaoyu Chen, Guiwu Qu, Ling Zhou, Maolei Xu, Qiusheng Zheng, Defang Li. Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25;9(8):302.
8) Boxue Ren, Lei Ye, Jianwei Gong, Huanhuan Ren, Yangfang Ding, Xiaoyu Chen, Xiaona Liu, Peng Lu, Fei Wei, Wenjuan Xu, Qiusheng Zheng, Defang Li. Alteronol Enhances the Anti-tumor Activity and Reduces the Toxicity of High-Dose Adriamycin in Breast Cancer. Front Pharmacol. 2019 Mar 29;10:285.
9) Chuanjun Qu, Weiwei Zhu, Kaijie Dong, Zhaohai Pan, Ying Chen, Xiaoyu Chen, Xiaona Liu, Wenjuan Xu, Haiyan Lin, Qiusheng Zheng, Defang Li. Inhibitory Effect of Hydroxysafflor Yellow B on the Proliferation of Human Breast Cancer MCF-7 Cells. Recent Pat Anticancer Drug Discov. 2019;14(2):187-197.
10) Boxue Ren, Defang Li, Lingling Si, Yangfang Ding, Jichun Han, Xiaoyu Chen, Qiusheng Zheng. Alteronol induces cell cycle arrest and apoptosis via increased reactive oxygen species production in human breast cancer T47D cells. J Pharm Pharmacol. 2018 Apr;70(4):516-524.
11) Defang Li, Ning Lu, Jichun Han, Xiaoyu Chen, Wenjin Hao, Wenjuan Xu, Xiaona Liu, Lei Ye, Qiusheng Zheng. Eriodictyol Attenuates Myocardial Ischemia-Reperfusion Injury through the Activation of JAK2. Front Pharmacol. 2018 Jan 30;9:33.
12) Huanhuan Ren, Jun Ma, Lingling Si, Boxue Ren, Xiaoyu Chen, Dan Wang, Wenjin Hao, Xuexi Tang, Defang Li, Qiusheng Zheng. Low Dose of Acacetin Promotes Breast Cancer MCF-7 Cells Proliferation Through the Activation of ERK/ PI3K /AKT and Cyclin Signaling Pathway. Recent Pat Anticancer Drug Discov. 2018;13(3):368-377.
2. 课题、获奖及专利列表
课题
山东省自然科学基金青年基金（项目编号：ZR2020QH326），山东省卫生健康委，2021-01至2023-12
获奖
山东省高等学校科学技术奖一等奖，山东省教育厅，2019.12，第三完成人
专利
李德芳; 郑秋生; 陈小宇; 刘晓娜; 郝雯瑾; 徐文娟; 羟基红花黄色素B在防治心肌缺血再灌注损伤方面的应用, 2020-1-3, 中国, ZL201810061748.0.
李德芳; 郑秋生; 曲传俊; 陈小宇; 刘晓娜; 叶蕾; 羟基红花黄色素B在制备治疗乳腺癌药物中的应用, 2021-2-26, 中国, ZL201810980739.1.
3. 著作
“十三五”规划教材《临床药理学》，吉林科学技术出版社，2020.10，第一副主编参与编写10万字以上
